生物安全实验室间气溶胶传播风险计算分析
摘要：结合某三级生物安全实验室工程，利用动态隔离理论进行了计算分析，结果表明：生物安全实验室核心间设置缓冲间是必要的；提高房间换气次数对隔离系数的影响不大；人员应急反应时间延长，系统隔离系数显著增大，可有效降低气溶胶传播的生物安全风险。
关键词：生物安全实验室缓冲间换气次数隔离系数污染物浓度气溶胶
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[2] 刘琦，卢耀勤，刘涛.国内外生物安全实验室的研究进展[J].职业与健康，2021,37(5):1724- 1728.
[3] PIKE R M.Laboratory-associated infections:incident,fatalities,causes and prevention[J].Annual review of microbiology,1979,33:44- 66.
[4] 魏强，李晓燕，王雷，等.近年病原微生物实验室获得性感染病例分析及其控制策略的初步研究[J].中华实验和临床病毒学杂志，2011,25(5):390- 392.
[5] WOOLEY D,BYERS K.Biological safety:principles and practices[M].5th ed.Washington,DC:ASM Press,2017:60.
[6] 杜茜，王洪宝，刘克洋，等.病原微生物实验室实验操作产生气溶胶风险定量研究[J].军事医学，2015,39(12):926- 928.
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Calculation and analysis of aerosol transmission risk between biosafety laboratories
Abstract: Combined with a three-level biosafety laboratory project, this paper uses the dynamic isolation theory for calculation and analysis. The results show that it is necessary to set up a buffer room for the core of the biosafety laboratory. Increasing the air change rate of the room has little impact on the isolation coefficient. The longer the emergency disposal time of personnel, the greater the system isolation coefficient, which can effectively reduce the biosafety risk of aerosol transmission.
Keywords: biosafety laboratory; buffer room; air change rate; isolation coefficient; pollutant concentration; aerosol;
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