新冠灭活疫苗生产车间暖通空调系统浅析

作者：高腾飞武程伟高鸿任彦准范双怀石巍

单位：中国电子系统工程第四建设有限公司北京生物制品研究所有限责任公司

摘要：结合建设经验及对相关规范的理解，介绍了新冠灭活疫苗生产车间中生物安全防护区暖通空调系统设计要点，从送排风系统、气流组织、压差梯度控制、空调自控等方面进行了详细阐述，建议新冠灭活疫苗生产车间空调通风系统送排风机均设置备用风机，防护区排风系统采用双级原位检漏过滤装置，并考虑定向气流、风口位置等因素满足生物安全的要求，制定合适的定、变风量阀控制策略，满足防护区压力恒定及工况转换的要求。关键词：新冠灭活疫苗;生产车间;暖通空调;防护区;送

关键词：风系统排风系统气流组织压力梯度

作者简介：高腾飞，男，1984年生，大学，高级工程师;*武程伟（通信作者）,050051河北省石家庄市中山西路356号中电信息大厦16层E-mail:sgchengwei.wu@cefoc.cn;

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参考文献[1] 盛方富，李志萌.重大突发公共卫生事件对经济的冲击、传导及其应对：以新冠肺炎疫情为例[J].企业经济，2020(3):12- 20.

[2] 国家卫生健康委、科技部、工业和信息化部、国家市场监管总局、国家药监局关于印发《疫苗生产车间生物安全通用要求》的通知：国卫办科教函[2020]483号[EB/OL].(2020-06-18)[2022-04-04].http://www.nhc.gov.cn/ qjjys/ s7948/ 202006/ 391e704a045944999 c565907f16ed579.shtml.

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[4] 农业农村部办公厅关于印发《兽用疫苗生产企业生物安全三级防护检查验收评定标准》的通知[EB/OL].(2018-10-26)[2022-03-29].http://www.moa.gov.cn/ nybgb/ 2018/ 201811/ 201901/ t20190102_6165929.htm.

[5] 亚太建设科技信息研究院有限公司，同济大学.生物安全实验室建设与发展报告[M].北京：科学出版社，2021:92- 95.

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Analysis of HVAC systems in COVID-19 inactivated vaccine production workshops

Gao Tengfei Wu Chengwei Gao Hong Ren Yanzhun Fan Shuanghuai Shi Wei

(The Fourth Construction Co., Ltd., of China Electronics System Engineering Beijing Institute of Biological Products Co., Ltd.)

Abstract: Through the summary of the construction experience and understanding of the relevant specifications, this paper presents the key technical points of HVAC system in the biosafety protection zone in the COVID-19 inactivated vaccine production workshop and elaborates the design details from the aspects of air supply system, exhaust system, air distribution, pressure gradient control, air conditioning auto-control system and so on. It is suggested that the standby fans should be arranged for air supply fans and exhaust fans in HVAC system of the workshop and the two-stage in-situ leak detection and filtration device should be adopted in the exhaust system in the protection zone. The directional air flow, air inlet or outlet location and other factors should be considered to meet the requirements of biological safety. Appropriate control strategies for constant and variable air volume valves should be formulated to meet the requirements of constant pressure and working condition conversion in the protection zone.

Keywords: COVID-19 inactivated vaccine; production workshop; HVAC; protection zone; air supply system; exhaust system; air distribution; pressure gradient;

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